ADmiRE

Annotative Database of miRNA Elements

Annotation wrapper for adding comprehensive miRNA annotations to a user supplied list of variants (tab-separated format)
Adds information for miRNA domains, gnomAD mean allele frequency percentiles, evolutionary conservation, etc.

Framework for microRNA variant annotation and prioritization using human population and disease datasets Human Mutation

Index	ADmiRE Annotations	Description
1	MIRNA	Precursor Name (miRBase)
2	PRE_ID	Precursor ID (miRBase)
3	Family_Name	miRNA Family Name (miRBase)
4	Family_ID	miRNA Family ID (miRBase)
5	Mature_Name	Mature Name (miRBase) (if applicable)
6	Mature_ID	Mature ID (miRBase) (if applicable)
7	High_Confidence	High Confidence (miRBase)
8	Conserved_ADmiRE	Conserved ADmiRE (This study)
9	Robust_FANTOM5	Robust miRNA (FANTOM5 project)
10	HMDD_Targets.PMID	Curated experiementally validated targets (PubMed ID) (HMDD)
11	HMDD_Disease.PMID	Known associated disease (HMDD)
12	miRTarBase_Validated.Targets	Curated experimentally validated targets (miRTarBase)
13	miRTarBase_TargetGene.Validation.type	Method of target validation (miRTarBase)
14	miRTarBase_Reference.PMID	Publication of target validation (miRTarBase)
15	gnomad_af_precursor_quantile	AF percentile from this study with mean AF across precursor miRNAs
16	gnomad_af_mature_quantile	AF percentile from this study with mean AF across mature miRNAs
17	gnomad_af_family_quantile	AF percentile from this study with mean AF across all mature miRNAs in a family
18	MIRNA_Feature	miRNA Domain (miRBase- Figure 1)
19	Precursor_Pos	Base position in precursor domain
20	Pred_Motif	Predicted Motif in Precursor (CNNC, basalUG, UGU, UGUG, loop)
21	Mature_Pos	Base position in mature domain
22	PhyloP_100way	PhyloP 100way- Vertebrate scores
23	PhastCons_100way	Phastcons 100way- Vertebrate scores
24	gnomAD_Count	gnomAD AC for all alleles at the position
25	gnomAD_MAF	gnomAD AF for all alleles at the position